A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands
نویسندگان
چکیده
منابع مشابه
A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.
We describe a general synthetic strategy for developing high-affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope of interest is synthesized as a polypeptide, with a detection biotin tag and a strategically placed azide (or alkyne) presenting amino acid. This synthetic epitope (SynEp) is incubated with a library of complementary alkyne or azide prese...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2015
ISSN: 0044-8249,1521-3757
DOI: 10.1002/ange.201505243